ECCMID Published Papers - Safety & Pharmacokinetics of i.v azidothymidine alone & combined with Colistin

P2195 Safety and pharmacokinetics of i.v. azidothymidine alone and combined with colistin being developed for the treatment of carbapenem - and colistin- resistant Enterobacteriaceae (phase-1-study)

Azidothymidine (AZT) in combination with colistin (COL) has in vitro synergistic activity against COL-susceptible and -resistant and carbapenem-resistant Enterobacteriaceae(CRE), including mcr-1-producing Escherichia coli strains. In this phase-1 study the safety, tolerability and pharmacokinetics of IV-administration of AZT and colistimethate sodium(CMS) alone and co-administered were assessed in healthy male and female volunteers.

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